Posted by SLS on April 21, 2010, at 6:32:57
In reply to Re: zoloft doesn't seem to help... » SLS, posted by Bob on April 20, 2010, at 21:10:07
> I would also like to add that your brain seems to be made of cast iron. From reading your posts over time, you seem to be able to go on and off these meds with hardly a second thought and almost negligible side effects in most cases.
I look at my tolerance of these medications to be a bad thing. I don't think my brain is likely to respond positively to such changes in drug exposure. My only robust and sustained response to medication was when using a treatment that produced pronounced side effects.
I wish I knew how to approach a case such as yours. I find it interesting that people report an increasing sensitivity to the negative effects of antidepressants as a result of previous exposures. Perhaps there is a sensitization (upregulation) of postsynaptic receptors as a result of a precipitous drop in neurotransmitter levels during drug discontinuation. I guess the genes that get turned on to produce this condition remain on. It might take an agent that inhibits second messenger cascades to turn these genes off. Lithium perhaps? I'm reaching. It is almost as if there is a kindling process occurring. Perhaps low dosages of AEDs would help.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:943917
URL: http://www.dr-bob.org/babble/20100416/msgs/944298.html