Posted by bulldog2 on April 16, 2010, at 17:25:22
In reply to Re: TCA's With Opioid Actions?, posted by linkadge on April 16, 2010, at 16:27:57
> This is it. I've heard some papers say that SJW (for instance) cannot possibly be effective cause it only inhibits the serotoinin transporter by 40-50%. Well true, but it affects dozens of other neurotransmitter transporters, receptor, and sinalling pathways.
>
> LinkadgeSo they're basing their conclusion on an unproved hypothesis. Which really makes the conclusion worthless. At this point you'd be better off testing thousands of herbs in the Amazon for antidepressant properties than trying to design another ssri or snri.
By the way I was put on a medrol pack for arthritis. The first day was 24 mg of Methylprednisolone and all I can say that really blasted me into a great mood that day. As the doses diminished so did the results. Curious as to what happens when cortisol receptors are hit. Or is that another receptor that has antidepressant quality. Actually better for me than opiates.
poster:bulldog2
thread:942955
URL: http://www.dr-bob.org/babble/20100416/msgs/943600.html