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Re: Any med that made you gain interest in people? » conundrum

Posted by SLS on April 15, 2010, at 18:24:41

In reply to Re: Any med that made you gain interest in people? » SLS, posted by conundrum on April 15, 2010, at 17:35:14

> Yeh I know how amulsipride works,

Which of its properties do you think is most responsible for its observed antidepressant effects?

> but all the other atypicals you mentioned are D2 antagonists and 5HT7 blockers as well as blocking the 5HT2A and 2C receptors,

It's too bad that ritanserin wasn't developed as an augmenter of APs and ADs.

> increasing norepinephrine in dopamine in the mPFC and decreasing it in other areas of the brain. Amulsipride doesn't do that

So, do you feel that the atypical APs are more potent as antidepressants than amisulpride? I tried sulpiride once. I experienced an immediate improvement for the first few hours after my initial dose. Thereafter, nothing. I'm guessing that the drug caused a release of dopamine until vesicular stores were depleted.


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