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Re: TCA-induced urinary retention » Viking

Posted by tensor on April 6, 2010, at 10:02:21

In reply to Re: TCA-induced urinary retention, posted by Viking on April 6, 2010, at 9:32:41

Unfortunately not. With TCAs the urinary hesitancy is an anticholinergic side effect. While in NRIs it comes from stimulation of alpha1-adrenergic receptors, that's why tamsulosin, which is an alpha1 blocker, helps.
Most TCAs are strong alpha1 blockers.

Thanks anyway,
Mattias

> Flomax (Tamsulosine) is often combined with Reboxetine to counteract the urinary retension caused by Reboxetine.
>
> I guess it will work with a TCA as well, as TCAs are also NRIs.


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