Posted by conundrum on March 25, 2010, at 22:34:49
I'm trying to figure out what to do next. The initial increase in color I experience from pristiq has faded at the beginning of the 3rd week. Too bad, but it is a very weak NRI. The brain probably quickly downregulated to adjust back to baseline.
I'm not sure what to do next. My GP will probably want me to try 100mgs, but I'm not sure it will be very useful. I think the color will return and then fade plus I will be swimming in too much serotonin.
So far the only drugs that have helped are 2.5 mg prozac with motivation and pristiq with color.
I'm considering just going along with my doc and seeing what happens. Other options are trying a stronger NRI like nortriptyline or Prozac plus adrafinil, which I would have to get from overseas. I wonder how much adrafinil could help though since I don't respond to coffee, ritalin, or wellbutrin.
Seems like I respond well to noradrenergic drugs and maybe antiserotonergic drugs. ie prozac's 5 HT2 antagonism.
Any ideas on what to do next?
Also I'm trying to figure out which NRI will improve cognition the most. I heard desipramine can help improve cognition. Some people also report feeling really good on vivactil. One that doesn't cause too strong palpitations would be nice.
poster:conundrum
thread:940895
URL: http://www.dr-bob.org/babble/20100318/msgs/940895.html