Posted by Brainbeard on March 17, 2010, at 5:27:20
In reply to SSRI - better response with less frequent dosing?, posted by linkadge on March 15, 2010, at 11:03:10
I'd like to add to Linkadge's original contribution that daily dosing schedules are based on practical considerations, not on what actually happens in the brain. The half-life of a drug and its blood plasma levels aren't predictive in a simple, one-on-one manner of its effects on receptors in the brain.
An example: Geodon's (ziprasidone's) half-life is very short, about 6-8 hours, but the half-life of its binding to 5HT2A-receptors is about 20 hours. Receptor binding typically lasts much longer than a drug's half-life.
It's just that for most people, having non-circadian dosing schedules would be too difiicult and lead to non-compliance.
poster:Brainbeard
thread:939632
URL: http://www.dr-bob.org/babble/20100305/msgs/939788.html