Posted by ed_uk2010 on March 14, 2010, at 6:47:22
In reply to Re: EMSAM/Selegiline vs. Adderall? » ed_uk2010, posted by Economist on March 13, 2010, at 19:20:58
>So what does Adderall do with dopamine, and what does EMSAM do?
As an MAO inhibitor, selegiline (Emsam) prevents the breakdown of neurotransmitters such as dopamine, serotonin and NE inside the neuron. It also blocks the breakdown of neuromodulators such as phenylethylamine. There are no MAO enzymes in the synapse.
Emsam increases the stores of monoamine neurotransmitters which are available for release into the synapse. It does not directly release them.
Amphetamine (Adderall) acts as a psycho-stimulant. It acts predominantly on dopamine and NE but serotonin is also affected. Amphetamine is believed to block the re-uptake of dopamine into the pre-synaptic neuron, thus increasing synaptic concentrations. It also forces larger amounts of dopamine to be released into the synapse, unlike MAOIs.
It is quite probable that MAOIs and stimulants effect dopamine neurotransmission in different parts of the brain. Amphetamines are often very reinforcing and have a high potential for misuse. MAOIs have a very low potential for misuse. This is because they have a different mechanism of action to the stimulants. The reinforcing properties of amphetamine have been linked to an increase in dopamine in the mesolimbic system.
poster:ed_uk2010
thread:939446
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