Posted by Hombre on March 11, 2010, at 8:49:54
In reply to Re: Who's taking Seroquel for (bipolar) depression?, posted by bleauberry on March 10, 2010, at 16:50:28
Remeron antagonizes the H1, 5-HT2A, 5-HT2B, 5HT2C, 5-HT3, 5-HT7, alpha1, alpha2A, alpha2C, mACh, and inhibits NERT.
Seroquel antagonizes H1, 5-HT1A/2A/2C/7, alpha1/2, and mACh as well as D1/2/3/4.
That's a lot of overlap. I guess I'm thinking that it might work well as an antidepressant and mood stabilizer for those who find Remeron helpful. But that's all on paper, and as you said it's hard to predict.
I'm not sure what the weight gain mechanism of Remeron and Seroquel is. I haven't had much trouble with Remeron in that regard. Stahl seems to think it's a myth that selective blockade of H1 receptors is responsible for weight gain.
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1916
Anyhow, always nice to hear other people's stories.
poster:Hombre
thread:938976
URL: http://www.dr-bob.org/babble/20100305/msgs/939154.html