Posted by Hombre on March 5, 2010, at 19:13:51
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=2541
PDF: http://mbldownloads.com/0210CNS_Stahl.pdf
Enhancing Outcomes from Major Depression: Using Antidepressant Combination Therapies with Multifunctional Pharmacologic Mechanisms from the Initiation of Treatment
New Trend In Psychopharmacology
Traditional guidelines call for treatment of major depression with a sequence of single antidepressants. Augmentation with a second agent generally only occurs when the first agent is well tolerated and when it also provides at least some symptomatic improvement on its own. Since this standard approach leads to low rates of attaining and sustaining remission by the first agent, with diminishing returns for each subsequent agent, there is growing dissatisfaction with this approach to the treatment of major depression. One new trend is to attempt to enhance the rates of sustained remission from a major depressive episode by combining two therapeutic agents from the very initiation of treatment of a major depressive episode.
[Article continues....]
poster:Hombre
thread:938644
URL: http://www.dr-bob.org/babble/20100305/msgs/938644.html