Posted by SLS on March 3, 2010, at 11:51:30
In reply to Re: Another indictment of antidepressants..., posted by CrAzYmEd on March 3, 2010, at 9:40:16
I think that most clinical investigations of antidepressants suffer from a lack of specificity when selecting subjects. I believe that too many people are included whom don't have the biological illness being studied. Often, the diagnosis of Major Depressive Disorder is left to the administration of primitive questionnaires comprised of 21 questions or less. No biological tests are given. Hopefully, this will change soon as more diagnostic markers are discovered. It is interesting that, statistically, people with more severe depressive symptomatologies respond better to antidepressant treatment. My guess is that these subjects are more likely to have Major Depressive Disorder. Therefore, the greater the proportion of the study population to present with severe depression, the more the results will demonstrate a greater effectiveness of drug treatment versus placebo.
- Scott
poster:SLS
thread:938402
URL: http://www.dr-bob.org/babble/20100216/msgs/938453.html