Posted by Brainbeard on February 21, 2010, at 8:42:55
In reply to Tricyclic most like SNRIs?, posted by bearfan on February 21, 2010, at 4:12:04
> Which one on the market is most similar to Effexor and Cymbalta? I have been trying nortriptyline, and do not seem to be getting any Serotonin/ relaxed effect. Just seems like an NRI.
I would say imipramine (aka Tofranil). Imipramine might be the most underrated and underprescribed antidepressant of our time. Effexor (venlafaxine) and Cymbalta (duloxetine) are actually inferior NRI's compared to the TCA's, so there's a big difference there. And Effexor surely is a much weaker SRI than imipramine and especially clomipramine (aka Anafranil), which is a very strong SRI as well as a strong NRI. Imipramine is a medium strong SRI and a strong NRI.
Ken Gillman, the TCA guru for some of us, wrote an interesting article comparing the properties of the old TCA's with new drugs like Effexor and Cymbalta: http://www3.interscience.wiley.com/cgi-bin/fulltext/121665024/HTMLSTART?CRETRY=1&SRETRY=0
poster:Brainbeard
thread:937524
URL: http://www.dr-bob.org/babble/20100216/msgs/937534.html