Posted by Garnet_LDN on February 5, 2010, at 22:07:00
In reply to Re: Low Dose Naltrexone Information » Garnet_LDN, posted by Green Willow on February 5, 2010, at 21:56:45
> Garnet, I take ldn (3 mg.) with great results, but I do have a problem with waking up in the morning since I have been on it. I have delayed sleep phase disorder and my natural circadian rhythm has me sleeping from about 3:30 a.m. till 11 a.m. I would like to readjust this (sleep doctor wants me to use light box for an hour every morning before 10 a.m.), but I simply cannot wake up that early since I have been on ldn. Before the ldn, I could set the alarm and get up in the morning earlier if I needed to, but since I've been on it, I just can't rouse myself no matter how hard I try. Would you have any knowledge about when my endorphins might be peaking and what my ideal time to try taking ldn would be? Is there any test (such as saliva testing or anything) to see when my endorphins peak? Thanks, Green WillowEveryone's endorphins peak at the same time, with the night time peak around 3 AM being larger and the afternoon peak around 1 PM being smaller.
If it is interfering with your schedule taking it in the evening then try to take it in the morning,
between 9 and 11 AM, should produce a peak blood level in time to affect the endorphin production at 1 PM.There are people who only take LDN twice a week or every other day, and they still benefit.
Dr Ian Zagon has stated that twice a week may be all that is needed, based on his research in animal models with LDN and Met5enkephaline, the main endorphin that is increased and through which LDN seems to work.
Due to tissue accumulation and variance in rate of clearing LDN some people do better taking it every other or every three days.
There are no clinically available tests for endorphins yet. They are limited to research environments, so yes they exist but not for patients unless you are in a study.
poster:Garnet_LDN
thread:933636
URL: http://www.dr-bob.org/babble/20100204/msgs/936089.html