Posted by jedi on January 11, 2010, at 2:16:14
In reply to questions for experienced Nardil users, posted by g_g_g_unit on January 10, 2010, at 21:16:07
> i just had a couple of questions regarding Nardil. the first time i tried the drug, i was scared off by the side-effects, so don't feel like i gave it a fair chance. i also titrated the dose too quickly, in my opinion.
> 1) firstly, i was just curious about how the drug impacts short and long-term memory? i remember feeling really fogged out and scattered. would it, for instance, be possible to study for a degree on the drug?
>
> 2) secondly, i got really bad restless leg syndrome and mycolonic jerks late into the trial, at around 75mg, which further disrupted my already tragic sleeping patterns. i guessed this might be because it's effect on dopamine transmission eases up? is the side-effect temporary, or at least dose-dependent?> 3) finally, is a sleep-aid a necessity while on the drug? again, is the insomnia dose-dependent? it seemed to begin to ease up eventually, but that was only because i was so exhausted from the sleep loss i think.
Hi ggg,
I'm a long term Nardil user and have tried stopping several times because of the side effects. Over about 12 years I stopped the med about 6 times. Each time my major atypical depression returned. I do have some short term memory loss but I blame that on concurrent use of clonazepam for the same period of time. This benzo is quite noted for disruption of memory. Hard for me to say what Nardil would be like by itself because I have always augmented with something. The one time I raised the dosage up to 90mg in a couple of weeks the side effects were much more pronounced than when I went up slowly.I have never had the restless leg or myoclonic jerks from Nardil. I did have some jaw clenching, but that was controlled with the clonazepam.
The side effects from Nardil are definitely time and dosage dependent. At high doses of 90mg and above (up to 120 in my case); I had pretty severe afternoon tiredness, insomnia, weight gain and delayed orgasm. On my current 60mg these symptoms are much milder. In the past 60mg would not control my major atypical depression. It seems to be doing the job now. I have always used something for sleep. Right now I rotate between 50mg of diphenhydramine hydrochloride(Benadryl) and 12.5mg of Seroquel. In the past I have used Trazodone. I am really sensitive to the histamine receptor medications.
One thing about Nardil, it is the BOMB(IMHO). When the medication works it can be truly amazing. If your depression is atypical, Nardil can work when no other medication does. And when it does kick in, it is not subtle. For me it was like flipping a switch. I did have some hypomania at first. This is not the true antidepressant effect of the drug. It feels good when you have been depressed for a long time and many people will mistake this for the true antidepressant effect. However, the hypomania will soon go away. Don't try to chase it, you won't find it. In fact after being off the medication for up to nine months, when I started it again, the hypomania never returned.
Just my experiences and we are all different,
Be well,
Jedi
poster:jedi
thread:933198
URL: http://www.dr-bob.org/babble/20100103/msgs/933217.html