Posted by willey on January 3, 2010, at 23:38:49
Everyone posting articles makes me so gitty!Lol in reality not that it means anything but im impressed at the angle this board took,seems as if everyones caught up to the ssri b.s
With everyone posting about maois,i think this article fits in nicely.
This articly in a nutshell,states how and why nardil instead of parnate increases gaba.
Also amazingly for the first time u see the two drugs spoken about togther in terms of their seperate methods of action.
In this snip,please take notice to what they say about nardils gaba increase,and that they state it is actualy reversed by pre treatment of parnate.
Parnate in a serperate article states it actualy DECREASES gaba,which to me explains why its usualy accompanied by use with a benzo,also possably explains the dramtic insomnia side effect that makes parnate such a pain in the bootax.
**********The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine **********
"The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine (TCP), suggesting that the GABA-elevating effect is largely the result of a metabolite of PLZ formed by MAO. In the present report, rats were pretreated with the nonselective MAO inhibitor TCP, the MAO-A inhibitor clorgyline and the MAO-B inhibitor (-)-deprenyl: at the doses used, clorgyline and (-)-deprenyl caused selective inhibition of MAO-A and MAO-B, respectively. Both TCP and (-)-deprenyl caused a greater reduction in the GABA-elevating action of PLZ than did clorgyline, suggesting that MAO-B is more important than MAO-A in the formation of the active metabolite of PLZ. The results also suggest that an effect other than, or in addition to, inhibition of GABA transaminase by the metabolite may be important in the GABA-elevating action."
poster:willey
thread:932418
URL: http://www.dr-bob.org/babble/20100103/msgs/932418.html