Posted by mtdewcmu on December 31, 2009, at 13:56:04
In reply to Re: Tandospirone » mtdewcmu, posted by SLS on December 31, 2009, at 13:23:48
> > > It is like adding lithium to a tricyclic in unipolar depression. By itself, lithium is usually inert.
> > >
> > >
> > > - Scott
> >
> > I read an article yesterday that stated that lithium is, in fact, an antidepressant in its own right. Here's another one: http://www.biopsychiatry.com/lithunidep.htm
>
> My choice of example might not have been flawless, but I hope I got the message across. I do question the conclusions of the paper you cited, but I would rather not get into a debate about it. They were looking only at the incidence of suicide, though, and not depression scores or rates of remission.
>
>
> - ScottStill, I think my original question is less trivial than it sounds. Why should a chemical show AD efficacy only when added to a second chemical? By eliminating some countervailing side effect of the second chemical? In that case, it should make a lot of difference which second chemical it's added to, because not all primary ADs will have that same side effect. Do you follow? I'm finding it a little hard to find the right words to express this succinctly. -- It's not at all obvious that there should exist chemicals that show no AD effect at all except when combined with a second effective therapy.
poster:mtdewcmu
thread:931601
URL: http://www.dr-bob.org/babble/20091227/msgs/931809.html