Posted by mtdewcmu on December 27, 2009, at 10:54:26
In reply to Re: Nighttime dysphoria and already on meds... » mtdewcmu, posted by bleauberry on December 27, 2009, at 6:46:31
> Well, I am relieved. You seem to have a smart plan and know what you are doing. You seem to be in more control of the situation than I was with mine several times. :-)
>Thanks. It does bother me that I'm still on 2 SSRIs. I am going down to 50mg of Zoloft this week.
> Back to the original symptoms, I suspect an adrenal exhaustion scenario. The largest dip of the 24 hour period probably occurs when you feel the sinking. If my hunch is correct, Remeron in particular is not doing you any favors, as it is putting additional stress on the already struggling adrenal glands. I know this particular topic pretty well and just thought it would be important to throw it out there in case someone else doesn't.
>I tried taking a low dose of Cortef each day a few years ago, and it didn't produce a noticeable benefit. I don't think it's an adrenal problem; I think it's entirely depression.
I think the sinking feeling when the sun goes down must be something akin to SAD.
Why would Remeron be worse than an NRI? Remeron blocks presynaptic alpha-2 receptors to achieve the same effect on norepinephrine.
> If my hunch were correct, a norepinephrine reuptake inhibitor holds a strong potential, through feedback loops and artificially boosting norepinephrine, to rebalance the entire network that is involved.
>
poster:mtdewcmu
thread:930897
URL: http://www.dr-bob.org/babble/20091227/msgs/931086.html