Posted by bulldog2 on December 5, 2009, at 13:28:53
In reply to Re: How fast do stimulants elevate mood? » Phillipa, posted by SLS on December 5, 2009, at 13:10:07
> > That three days again. Phillipa
>
> Yes. I imagine that the key to my treatment-resistance lies in some biological process that takes three days to complete.
>
>
> - ScottI have the same problem with stimulants. After several days they cease to work. Sometimes an increase in dose will start them working again. But soon they don't work at any dose.
It could be that it's a problem with rapid tolerance and expulsion of the drug. Or maybe the body becomes depleted of the neurotransmitters that the stim works with. If one is depressed one theory is we're running low on certain neurotransmitters. So the stim exhausts what little we have left.
Have you ever tried a stim with an maoi? There would be more available material to work with.
or a drug such as memantine with the stim to prevent tolerance which worked for andrewb.
poster:bulldog2
thread:928145
URL: http://www.dr-bob.org/babble/20091127/msgs/928194.html