Posted by Phidippus on October 31, 2009, at 19:01:08
In reply to Re: tianeptine and piracetam, posted by friedokra1 on October 30, 2009, at 15:39:10
> thanks,
>
> what is the difference between modulation and antagonism?The NMDA receptor is modulated by a number of endogenous and exogenous compounds:[15]
Usually modulation involves blockade of the NMDA channel in some manner but also potentiation of some NMDA-induced responses-in other words modulators turn the sites on and off.> what does modulate even mean when we are referring to a neurotransmitter?
Inhibiting and potentiating a receptor site-like switching it on and off.
> what about AMPA as it relates to tianeptine and piracetam?
Piracetam is a positive modulator of AMPA-sensitive glutamate receptors - turning it on more than off - greater potentiation.
tianeptine rapidly increased the amplitudes of NMDA- and AMPA.
P
poster:Phidippus
thread:923442
URL: http://www.dr-bob.org/babble/20091029/msgs/923733.html