Posted by Sunbath on October 14, 2009, at 6:43:04
In reply to Trazadone and Parnate, posted by Maxime on October 13, 2009, at 17:47:03
Hi Maxime!
Even regarding the manufacturer of Parnate in Germany it's possible to combine Parnate with trazodone (and with amitriptyline and other TCAs). BUT they say it's only recommended when you started the tca before or while you are starting Parnate.. not after. However some ppl also on babble, I think it's Scott, but please ask him yourself as I can't say for sure anymore, tried doing it the other way round (not amitriptyline I think but it might have been nortriptyline) and it worked without any problems.. I also tried adding ultra low dose amitriptyline (10-20mg) a few days before and it was no problem at all.. I think that might be because that's a really low dose.
Regarding trazodone: it's such a weak serotonin reuptake blocking agent, that it seems impossible to cause any serotonine syndrome except maybe in ultra high doses.. Its affinity for the SERT is about Ki 600 where's amitriptyline's affinity is about Ki 4 I think. So amitriptyline is soooo much more potent and even that is possible to combine with Parnate (at least when you watch out for the right order, i.e. starting it before beginning Parnate therapy).
It might well be that I don't get something, but isn't the only real danger when you are combining TCAs the possibility for serotonin syndrome? Then I can't understand why trazodone could be dangerous at all! I think it's just in the contraindicated list because it theoretical is a sri, but practicly it's just a 5ht2a/2c antagonist that helps with sleep :)
Well that's only my thoughts and I'm really not competent and of course no doctor.
But even my doctor -who never prescribed Parnate before and who is quite cautiously- allows me to take 200mg trazodone/night (but that's an extended release version!).Maybe your doctor would let you do it?
Good luck to you!!!! I really hope that it will work out for you this time!!!
poster:Sunbath
thread:920819
URL: http://www.dr-bob.org/babble/20091012/msgs/920880.html