Posted by yxibow on October 12, 2009, at 11:55:51
In reply to SLS, yxibow, linkadge other experts...., posted by Jeroen on October 11, 2009, at 16:15:50
> Hi all experts of this board
>
> You all knpw of my short success with Seroquel
> now there's a tolerance for 5 years going on, doesnt help anymore
>
> i need to know why it did work, and its the only anti psychotic that worked.. the rest atypicals didnt do jack..
>
>
> i'm open to your things what i should do next and ask my doctor
> i'm despirate
Its probably the same reason Seroquel gives me functionality but doesnt work "the same as it did before" (taken for nearly 8 years, 5 better years of those).
Neuroplasticity and shifting of biochemical imbalances mean that continuous use (of most psychotropics, btw) keeps attempting to hit transmitters that have already been hit too much.
I made an analogy with my doctor.. basically its like trying to hit a nail through hardwood with a rubber mallet.It may go through occasionally... but it doesn't go through all the time and the transmitters are saying "we're over saturated"
You've been through quite a merry-go-round of atypicals if I do say -- and that's probably double a reason why the Seroquel is not working.
Piling up them can be unpredictable.
At this point if it isn't working, you'll have to do a "washout". I wish I could but like everything in my illness, its a catch-22.
I would be reduced to very low functionality and I would be confused and anxious and possibly paranoid about certain things.
But (like myself) I know you're determined to get results.
The only way I see it is to slowly reduce and discontinue your antipsychotics. A few weeks or a month or so must pass at least WITHOUT ANY medication.
That means you must be monitored in a hospital, as your case is complex and I would be concerned about your safety and well being.
Then, and only then would you rechallenge ONE antipsychotic, be it Seroquel or Abilify.And you MUST follow through with the medication for up to three months without dropping it at all, even if you have some side effects that I understand are not pleasant.
You can't count "Day 19", etc. You just have to keep going on as best as you can.
This, I believe is the best chance for you.
I only wish I could try the same for myself.
-- best wishesJay
poster:yxibow
thread:920517
URL: http://www.dr-bob.org/babble/20091012/msgs/920613.html