Re: SLS - TCA question

Posted by SLS on September 14, 2009, at 6:14:50

In reply to SLS - TCA question, posted by linkadge on September 13, 2009, at 19:06:00

> How much nortriptyline is produced by amitriptyline?
>
> Do you know of any literature on this?
>
> I.e. if I take 100mg of amitriptyline, it would produce the equivalent blood level of nortriptyline of what dose of nortriptyline?
>
> Linkadge

That is a great question. I haven't a clue. With imipramine, desipramine predominates by quite a large margin once steady-state is achieved. However, I believe the metabolic pathways of the two parent drugs are different enough from each other that one could not extrapolate from imipramine the behavior of amitriptyline.
One study determined the mean ratio of NT/AMI at steady state to be 0.962. I found it difficult to find anything else as relevant.
http://www.ncbi.nlm.nih.gov/pubmed/3576661?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

- Scot

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SLS - TCA question linkadge 9/13/09
Re: SLS - TCA question rjlockhart04-08 9/13/09
Re: SLS - TCA question SLS 9/14/09
Re: SLS - TCA question linkadge 9/14/09

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