Posted by SLS on September 13, 2009, at 5:35:51
In reply to stim/NRI - also, NRI time delay, posted by desolationrower on September 13, 2009, at 1:52:59
> i wonder if NRI effect which is often said to 'take two weeks' is mostly the reverse tolerance aka dopaminergic sensitisation
When treating depression, I think it may be possible that the first thing that occurs upon the initiation of reuptake inhibitor antidressant treatment is the accommodation phenomenon of the postsynaptic neuron whose receptor membrane is bathed in too much neurotransmitter. This results in a reduction of action potentials produced. Then, over days or weeks, the postsynaptic neuron responds by downregulating its receptors via reducing their numbers, and this allows the neuron to begin firing again. The net effect of this might be to reset the feedback loops that more approximates the normal synaptic dynamics, despite a decrease in the signal-to-noise ratio.
- Scott
poster:SLS
thread:916581
URL: http://www.dr-bob.org/babble/20090912/msgs/916830.html