Posted by SLS on August 31, 2009, at 15:42:46
In reply to Parnate technical, posted by willyeee on August 31, 2009, at 14:18:21
> This is a tiny bit technical.ok some meds have there metabolites made into a med themselves.Its been argued that parnates metabolite is that close to a amphetamine,which makes sense since a metabolite shows up when the drug is leaving hence the insomia.Also however with the insomnia i notice my mood does actualy improve,just to damn late for any of this.
>
> So to make this short,i i looked and looked,could not find any hard info on what the parnate metabolite is,only that parnate holds a 2.5 half life,my thinking is can we look at using the metabolite as a med as other drugs have done since we see how it acts so strongly.
>
> Hope this makes sense thanks.Post-mortem studies of Parnate overdose victims have not tested positive for amphetamine or metabolites.
- Scott
*************************************************81: J Anal Toxicol. 1996 Sep;20(5):301-4.Links
One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites.
Iwersen S, Schmoldt A.Department of Legal Medicine, University of Hamburg, Germany.
Two very different cases of overdose with tranylcypromine are presented. One clinical case involving the ingestion of 400 mg tranylcypromine with suicidal intention and one fatality with a suspicion of possible tranylcypromine overdose were examined. Both cases showed similar blood concentrations (0.5 and 0.7 mg/L, respectively), but the clinical case exhibited only mild symptoms of intoxication. The fatality showed no other drugs that could provide an explanation for the death of a 40-year-old male except tranylcypromine. Consideration of the drug concentrations in the fatality in relation to the case findings and other reported data indicates the tranylcypromine overdose as the probable cause of death, despite the low blood concentration. In addition, we looked for evidence of amphetamine as a putative metabolite in both cases. No amphetamines were detected in the overdose cases reported here.
poster:SLS
thread:915079
URL: http://www.dr-bob.org/babble/20090826/msgs/915083.html