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Re: A thought on Lyrica and benzos.... » Sunbath

Posted by SLS on August 30, 2009, at 16:22:57

In reply to Re: A thought on Lyrica and benzos...., posted by Sunbath on August 30, 2009, at 14:49:46

> Hi jms!
>
> I was also very interested in Lyrica and from what I've read, Lyrica doesn't work "at the same site" as Benzos nor does it mimic gaba. And it doesn't just only increase gaba levels either.. it does a lot of other things..

That's a real good synopsis. I don't know all of the things that Lyrica does. I do know that it binds to the alpha2delta subunit of the voltage-gated calcium channel and inhibits it. Neurontin does the same thing. To my knowledge, neither drug influences sodium channel function.

My brain does not like either of these two drugs. They make my depression worse and make me feel like a zombie. What's worse, is that I continue to experience these things long after I discontinue the drugs.


- Scott

 

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