Posted by SLS on August 16, 2009, at 16:22:33
In reply to Re: Mildest SSRI or SNRI?, posted by Sunbath on August 16, 2009, at 15:18:58
> I'd also like to know. I always thought lexapro to be the "mildest" ssri? Being the most selective of the ssris (is that true?) and with a lower affinity to the SERT than paxil, zoloft and prozac? Would that also mean that Lexapro theoretically wouldn't work as good in treating OCD as paxil, zoloft and clomipramine?
For some reason, it is the subjective description of many people that Zoloft is the smoothest of the SSRIs. Of course, there are people for whom this is not true. "Smoothness" may not be directly attributable to the binding affinities at the SERT of the different SRI medications. It might also depend on differences in the location of the brain where the different drugs accumulate. Also, I would guess that the other various properties that these drugs possess affect efficacy and tolerability.
Dosage does not always indicate binding affinity.
http://www.preskorn.com/books/ssri_s3.html
Damned drugs.
- Scott
poster:SLS
thread:912430
URL: http://www.dr-bob.org/babble/20090810/msgs/912451.html