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Re: Anafranil plus Reboxetine plus Wellbutrin

Posted by SLS on August 3, 2009, at 6:34:30

In reply to Anafranil plus Reboxetine plus Wellbutrin, posted by Meltingpot on August 3, 2009, at 2:17:28

> Hi,
>
> Well I don't think that the 4mg that's been added to my clomipramine (Anafranil) has been doing a lot and I've been on it for about 2 weeks. I know my psychiatrist will want me to give it 5 to 6 weeks but I'm impatient to try something else.

If you are talking about using reboxetine here, I don't understand the rationale for trying it. The metabolite of clomipramine, desmethylclomipramine, is a potent NE reuptake inhibitor. Perhaps the rationale is simply that you haven't tried it before.

> I plan to stay on the clomipraine (Anafranil) and Reboxetine for 5 weeks because I want to give it a good try but in the meantime I have wellbutrin in my drawer and was wondering if it would be safe to take 300mg of that a day. I was thinking of maybe taking it for a week to see how it affects me.

I would dump the reboxetine first and then add the Wellbutrin to clomipramine.

I have a personal bias against reboxetine. It made me far more depressed with anxiety and suicidality. I don't see very many people singing its praises. I don't think the drug is effective in as large a percentage of the population as are most other antidepressants.

Give consideration to using Zyprexa or Geodon every day instead of "pulsing" it ever few days. You want the brain to reset itself to a new equilibrium. Pulsing Zyprexa might be preventing that from happening. Geodon represents an alternative to Zyprexa. It can act as a potent potentiator of antidepressants. If it doesn't work within a week or two at 40-80mg, it probably won't. If it produces undesirable effects, you just switch back to Zyprexa the next day. You get your answer pretty quick.


- Scott

 

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