Posted by bleauberry on July 19, 2009, at 7:17:58
In reply to Grapefruit Juice and MAOI's, posted by FrequentFryer on July 18, 2009, at 5:15:00
I am not sure of a way to predict how much grapefruit juice someone would need to affect xanax levels. Someone with chemistry expertise could probably figure something out. But even then, liver stuff varies widely from person to person. For example in a study when zoloft was added to nortriptyline in a group of people their blood levels of nort were increased by a very small percentage near zero to a very large percentage almost near 100%. I don't recall the exact numbers but it was quite a spread, showcasing how we all metabolize stuff differently.
Grapefruit juice does most of its liver influence on drugs if they are taken at the same time. It primarily affects the first pass metabolism. For example if you took Parnate or Nardil at 7am, and then had a glass of grapefruit juice at 11am, there would be hardly any effect.
I am not a pro on this particular topic but that is how I understand it.
poster:bleauberry
thread:907312
URL: http://www.dr-bob.org/babble/20090709/msgs/907466.html