Posted by jrbecker76 on July 1, 2009, at 15:02:09
In reply to Should I drop reboxetine/edronax or........, posted by cactus on June 30, 2009, at 19:08:27
> lower my does again? I started on 8mg. 4mg twice a day and it was fantastic to start with. Then after 2 months I noticed I started getting very agitated and irritated very easily. I lowered my does 2 weeks ago to 6mg a day. 4mg am 2mg pm and it's still not getting any better. Today I'm starting 2mg am 2mg pm to see if this helps.
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> The main reason I don't want to stop taking it is because it has stopped racing, intrusive thoughts, dead in it's tracks. Literally after the 1st dose.
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> No AD has ever done this for me before. I have a high pressured job and can't figure out whether or not to be irritable or stuck in my brain on spin cycle and be off my game, but people are starting to notice, and I'm becoming a real pain in the butt to work with. TCA's, SSRI's SNRI's and MAOI's are not an option.
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> I noticed other people comment about this but I thought no, I'm fine, this is the best AD I have ever taken, but it has started to happen to me.
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> I have lowered my modafinil to 100mg a day and my clonazepam to 5mg a day.
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> Any feedback would be greatly appreciated. Peace CFirst off, be wary of lowering your klonopin at the same time of making reboxetine switches. As mentioned in a prior thread, I had some significant issues with irritability/emotional lability on reboxetine. I never got passed a week in the number of times I have tried it. I can certainly agree with you that the noradrenergic effects are great for focus and shunting intrusive thoughts. It also made me more productive. However, the issue remained that there would be a lower threshold for emotional instability and sometimes even negative thinking. In the end, I found this too big of a tradeoff. Surprisingly, my reaction to Seroquel was similar in this regard but not as bad (the drug and its metabolite have strong NE activity). I am an unusual case though, since as you know, Seroquel has been a great drug for most.
Are you taking anything else that would be synergizing with the noradrenergic effects of the reboxetine (e.g., effexor, cymbalta, seroquel)?? Along those lines, I would look to see if you could switchout reboxetine and "soften" the noradrenergic effects by trying another NE drug but with a more diversified mechanism of action, such as 1) Savella or 2) Seroquel.
Good luck.JB
poster:jrbecker76
thread:904035
URL: http://www.dr-bob.org/babble/20090630/msgs/904233.html