Posted by garnet71 on June 7, 2009, at 13:43:20
In reply to What to Expect? Going from Effexor to Cymbalta, posted by butternut on June 7, 2009, at 13:04:32
I did a quick search...although most refer to GI bleeding, I found something interesting:
"Results
There are over 120 MEDLINE-cited peer-reviewed research papers and more than 50000 Web pages devoted to SSRI-related bleeding events.Conclusion
Independently of the brand, use of SSRIs is indeed associated with increased bleeding risk. Although such complications are rare, their frequency is growing, and physicians should be aware of SSRI-induced hemorrhages, especially in patients with hereditary platelet defects, and those treated with antiplatelet agents. Prospective studies are urgently needed to determine whether SSRIs will yield additional bleeding risks when used long term concomitantly with aspirin or clopidogrel.There is also emerging evidence that these side effects of SSRIs are due to blockade of serotonin reuptake in platelets and subsequent platelet dysfunction."
This study was inconclusive, but mentions blood platelet effects:"Conclusions: Our patient demonstrated an idiosyncratic hypersensitivity to the platelet inhibitory effects of venlafaxine. Because venlafaxine is an inhibitor of serotonin uptake by platelets and neurons, this mechanism may contribute to the impact of this drug on platelet function. However, our in vitro studies suggest that this hypothesis is inadequate to explain the observations completely."
These articles barely mention bruising, but I thought they interesting. The 2nd is a power point about adverse affects of drugs. I also having been finding the nursing journals seem to focus on adverse effects of antidepressants; i've found good information in some of them in the past. You might want to look there.
http://www3.interscience.wiley.com/journal/118553543/abstract?CRETRY=1&SRETRY=0
http://www.nursing.theclinics.com/article/PIIS0029646502000695/fulltext#section11
poster:garnet71
thread:899832
URL: http://www.dr-bob.org/babble/20090531/msgs/899836.html