Posted by SLS on May 20, 2009, at 22:32:58
In reply to Seroquel help needed!, posted by ricker on May 20, 2009, at 13:34:18
> Hi all,
>
> I started seroquel 3 weeks ago and felt great for 2 weeks. The last 3 or 4 days feels like a switch has been flipped?? I'm getting extremely irritable, expesially in the morning and my jaw seems to be clenching causing pain just below the temple area. Slight muscle spasms in the legs after taking seroquel as well.
>
> I'm taking 100mg so I was wondering if decreasing to 50mg would help.... less irritability, jaw clenching and muscle spasms? Or does it sound like seroquel may not be for me?
>
> I have zydis available and may consider restarting it if I don't get any positive feedback from this post, at least I didn't experience these symptoms when taking it. I could probably live with the zydis weight gain as compared to how I'm feeling now!
>
> Just not fair, feeling good for 2 weeks and now this???? What to do :-(
>
> Rick
Hi Rick.I think yxibow (Jay) would be a better source of information regarding neuroleptic antipsychotic side effects.
Seroquel has a major metabolite that is a norepinephrine (NE) reuptake inhibitor (like desipramine or reboxetine). Perhaps this produced an energy boost acutely early in treatment that disappeared and turned into dysphoria and anxiety after chronic administration.
Let me sleep on this stuff.
For now, either leave things as they are and hope for a return of an antidepressant response or experiment with both lower dosages and higher dosages.
- Scott
poster:SLS
thread:896829
URL: http://www.dr-bob.org/babble/20090515/msgs/896917.html