Posted by garnet71 on May 14, 2009, at 23:05:06
In reply to Oral Selegiline + Emsam Patch?, posted by HopeSprings on May 14, 2009, at 20:29:09
Well Segeline via Ensam patch is delivered transdermally to directly enter the bloodstream in order to bypass the digestive system...something to do with the metaboliziation of tyramine in the digestive system/intestines that the MAOI inhibits. I think, but not sure, it was created to avoid the potential hypertension side effect from certain tyramine foods; an accumulation of tyramine can cause the hypertension.
I don't know what other benefits there are to transdermal delivery, but whoever came up with that idea was thinking out of the box, and I hope to see more of that type of thinking when it comes to drugs.
It also makes me wonder why they don't invent patches for drugs that are metabolized by the liver rather than the digestive system; drugs that might damage the liver. Maybe it doesn't work with other drugs, I have no clue.
poster:garnet71
thread:895841
URL: http://www.dr-bob.org/babble/20090505/msgs/895869.html