Posted by Vincent_QC on May 14, 2009, at 12:15:37
In reply to MAOI fatigue, posted by desolationrower on May 13, 2009, at 3:09:52
> just thinking - perhaps fatigue from MAOIs is from the increase in melatonin levels, messing with sleep cycle. too bad theres no melatonin antagonist
>
> -d/rMaybe the fatigue is also caused by the effect of the MAOI on the heart...hypotension, sometimes hypertension and high blood pressure not related to food interraction...
One thing is sure, the Parnate was the one who caused the more fatigue. I write only on me because we are all different... maybe it can do the opposite effect on others peoples... but for what I read , it's seem to not be the case...no wonder why a lot of peoples ask to have something to augment it (Ritalin...remember Jadekelly...), that's one of the best example of the fatigue caused by the MAOI's...
It's certainly not a stimulant MAOI (Parnate), like a lot of peoples think... the fatigue I had while I try it was more a physical ones, muscles fatigue with weird effect on my heart... I notice the same effect(hypotension orthostatic) on the Nardil as well but only at 90mg...not at 75mg...at 75mg, I was able to eat what I wanted, never monitered my BP, I was taking my pills 3 times a day and forget it...and the diet...
On the Parnate it was another story... I had a GOOD reaction on it for the social phobia... in fact, that's the only one med who do something on my social phobia...but I had so many side-effects to deal with, that even if everyone told me to stick on it at the small 40mg dose that I taked for 3 weeks... it was impposible for me to continue it... It's the kind of experience I don't wish to my worst ennemy!!! I total nightmare... making all the newer AD's very innofensive for me...
For no reasons I had hypertensives crisis and I had also in the same day hypotension orthostatic...so I guess the Parnate hit a place in the brain who control the heart...but where? I don't know... I'm not a Pharmacist and a PDoc or a Doctor so I can't answer... even the GSK compagny don't seem to know what the Parnate do in the brains... so the heart effect is probably linked a lot to the fatigue... That's what I think...
For the Marplan, I will never know, because it was approved for me as an importation drug, approved by Health Canada, BUT, I had to pay for it...180 $ (Canadian) for a 56 pills bottle... In fact, the PDoc had to send the payment to health Canada, who will send the command to the compagny in the New-Jersey. BUT because it's not manifacturing in the States but in Finland, I will have to pay for the Marplan...Normally, Health Canada deal with the USA compagny and pay the bill...but not this time... So when HC receive the payment, they send the RX to the USA compagny and that compagny will send the product back to HC who will inspect it and send it to my PDoc. The PDoc have to produce a report after the trail of the Marplan...it's like I will became a study subject for the drug...like I will test it and make a report to Health Canada...but I have to pay it...mean 60mg/day (target dosage), mean 6 pills a day, mean 9 days for a bottle , mean a total of more than 540$ each month!!! I don't work and it's not cover by any inssurance plan...so forget it... The Emsam patch will be less expensive I think...and I Can't afford it...
So i'm on the Pristiq since 2 days... sample bootle of course... if it's work, I will be pushed by the compagny, so it will cost nothing for me... Since I start it, I don't have any side-effect. It's the first time I experience an AD without any side-effect...that's weird cause it's the active metabolite of the Effexor-XR, and the Effexor was very bad for me, increasing my anxiety level in general and make me totally not sociable...and craving for MORE benzo drugs... The Pristiq seem to be a clean med to me... I will see the result , I give it a try for 1 month...
If it's not doing anything for the SAD or the GAD, I will switch again on the Nardil...and ask to use off-label meds to help me more...Sabril or valporic acid will be my next move I think... I will see... for now I take my small pill of 50mg of Pristiq and forget it... sometimes, when I feel my BP is high, I take a clonidine pill (0,1mg)...and my BP return to the normal 120/70...
Life cant be worst for me...I continue to hit the gym 4 evening a week, even if I have panic attack sometimes and that I have a big difficulty to stay in my own bubble... I tend to look around me and at all the peoples and I can't concentrate, so I begin to be shy, my heart beat increase and BANG it's the panic attack... I have to learn how to control myself and forget the others peoples around me...
At daytime I feel a lot tired and return in my bed often...I just smooke, eat and answer to my emails, sometimes visit facebook site...but not for a long period of time....
Ho and I forget... I use 30mg of Valium (10 morning, 10 afternoon and 10 evening) + 2 mg of Rivotril on purpose... I don't use the Rivotril each day...just in extreme emergency case and in special exposure social events, like at the gym or if I go out in a bar or something like this... I found out that the use of this 2 benzo drugs together have a more strong effect for the social phobia and general anxiety than just use the Valium or the Rivotril alone...and in that way , I keep the control over my high tendancy to developp an addiction on the Rivotril, like I had before... I feel in control over my benzos intake, that's a major step in the good way for me...
Thanks!
VIncent ;-)
poster:Vincent_QC
thread:892721
URL: http://www.dr-bob.org/babble/20090505/msgs/895770.html