Posted by NegCreep on May 8, 2009, at 11:41:31
In reply to Re: Anyone in clinical trials for Lu AA21004 ?, posted by iforgotmypassword on May 8, 2009, at 1:54:58
Yeah Id prefer a new mechanism of action over a SSRI any day. PArticularly since 5-HT1a agonism is particularly good for anxiety (I have GAD) Although vilazodone is an SSRI with no reported sexual side effects (yet)....maybe not so bad? Ill probably try both anyway :)
Neg
> i prefer the sound of this drug over that other 5-HT1a agonist in the pipeline, vilazodone i think it is called, which seems to lack the effects of a real 5-HT1a agonist in vivo. it's actual relevant action may be it's supposed "secondary" SRI effect. just what we need, another SSRI to waste time promoting.
>
> this drug, Lu AA21004, appears to be a real 5-HT1a agonist, that is to say it releases catecholamines in the PFC as associated with the actions of an 5-HT1a agonist. curiously however, it also increases extracellular serotonin, an effect very unlike what is expected with 5-HT1a agonism, which is supposed to decrease extracellular serotonin concentrations. this may be an effect of the 5-HT3 antagonism, i would like to know more about that, and where exactly the extracellular serotonin concentrations would be increased and what the neuropsychiatic complications may be understood or theorised as being.
poster:NegCreep
thread:894465
URL: http://www.dr-bob.org/babble/20090505/msgs/894768.html