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Re: Augment Nardil w/ Memantine b4 or after 'poopout'? » desolationrower

Posted by SLS on May 4, 2009, at 6:12:13

In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by desolationrower on May 3, 2009, at 23:20:40

> > > So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
> >
> > No data.
> >
> > Just guesses.
> >
> > I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
> >
> > A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
> >
> >
> > - Scott
>
> isn't this just an artifact of the fact that maintaining non-depressed state is easier than causing remission?
>
> -d/r
>
> PS hi myco good to see you are you ok from pnomoneua?

Not really. I witnessed one woman who was brought out of a severe depression that had lasted several years by her taking lithium. She remained absolutely healthy for over eight years. Then she changed doctors. The new doctor decided that his first intervention would be to have her discontinue the lithium. She relapsed into depression three weeks later, whereupon lithium was restarted at the same dosage. Nothing. The therapeutic response was not recaptured. She is going on 20 years of unrelenting double depression despite being a research patient at the NIMH for over 1 1/2 years and trying just about everything out there.

My own story reflects hers. I once responded with a 100% improvement - total remission - using a combination of Parnate and desipramine. It never pooped out. However, my doctor at the time had me discontinue it. When I relapsed two months later, he gave me Parnate only. For months I languished while I let him play with dosages. Then, when desipramine was again combined with Parnate - nothing. I could not recapture the therapeutic response.


- Scott

 

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