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Re: Stopped Luvox - how soon can I start Nefazodone?

Posted by SLS on May 3, 2009, at 7:04:47

In reply to Stopped Luvox - how soon can I start Nefazodone?, posted by brooke484 on May 2, 2009, at 18:14:31

> Luvox must not agree with me. After only two days on 12.5 mgs I can't take it anymore. I'm not even willing to tough it out. So I'm going back on a low dose of Nefazodone. Just wondering how long I have to wait to start.


I would echo what Jay said. That you have so little Luvox in your system shouldn't create a situation that would produce serotonin syndrome. The half-life of Luvox is about 15 hours. Nefazodone will not inhibit or slow down the clearance of Luvox. You can cross over to nefazodone as quickly as you can tolerate any side effects.

Luvox: Inhibits CYP4501a2
nefazodone: Inhibits CYP4503a4

Neither drug affects the other's metabolism in the liver. They are not competitive substrates for the same enzymes.


- Scott

 

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URL: http://www.dr-bob.org/babble/20090426/msgs/893993.html