Posted by Larry Hoover on April 30, 2009, at 22:42:47
In reply to Supplements to replicate Lamictal / Riluzole, posted by uncouth on April 30, 2009, at 15:37:53
Taurine is a direct modulator of glutamatergic receptors. It will completely abolish any side effects from MSG, for example, in the periphery. And it crosses the BBB and does the same in the brain and CNS.
There are dedicated taurine uptake pumps in the brain, and it is co-released with glutamate into many synapses. The difficulty with using it as an exogenous modulator is that it is a natural neuromodulator already, and there are all kinds of ways the body will regulate the duration of the effects. That's one reason why drug effects are hard to replicate with natural substances. Drugs work so potently because they are foreign to the body, and escape many regulatory and metabolic control mechanisms.
Lar
poster:Larry Hoover
thread:893593
URL: http://www.dr-bob.org/babble/20090426/msgs/893656.html