Posted by SLS on April 13, 2009, at 15:23:08
In reply to Re: Enjoy, posted by Alexanderfromdenmark on April 13, 2009, at 12:18:53
> > Of course it does.....the dopamine pathway and the seratonin pathway are link through other compounds....you increase on and it "uses up" more than its normal share of enzymes thus reducing the availability of that enzyme for the other pathway.
> >
> >
> > > 5-htp depletes dopamine
> > >
> > > http://www.neuroassist.com/5-HTP-depletes-dopamine.pdf
> >
> >
>
> Well wasn't that question the point of this thread?
This is a fascinating study. One must remember, though, what it is they actually looked at - synaptosomes. These are little droplets of cell membrane extracted from the brain and placed in petri dishes outside the animal (in vitro). This is not the natural environment within which neurons function (in vivo). In vitro, the entire set of synaptosomes are being bathed in a liquid containing 5-HTP and serotonin (5-HT). Serotonin will not enter a cell without having a serotonin transporter (SERT) to facilitate it. That leaves us with the possibility that serotonin is entering the synaptosome through passive transport, rather than being excluded from entry as it is in vivo.This is a study of membranes produced artificially and bathed in a synthetic medium with a substance normally not found outside the cell in vivo. What it is not, is a study of circuits.
I don't know enough to be able to comment on whether or not this study is an accurate representation of what we are looking for. Is dopamine being displaced by serotonin entering the cell, or are dopamine circuits being turned off by the overactivity of serotonin circuits?
- Scott
poster:SLS
thread:889611
URL: http://www.dr-bob.org/babble/20090408/msgs/890385.html