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Re: Dopamine depletion: A myth?

Posted by bleauberry on April 9, 2009, at 16:11:00

In reply to Dopamine depletion: A myth?, posted by SLS on April 9, 2009, at 8:10:25

I don't know if I could find it again, but one day surfing on pubmed I came across a study on rats where they showed that longterm ssri's caused the excess serotonin to be taken up by dopamine neurons. Theoretically an effort by genetic coding to deal with the artificially increased serotonin. If that is true, it would go a long way to explain poopout and ssri apathy syndrome. Serotonin getting involved in the dopamine circuits could do weird things like that, I imagine.

There must be some crosstalk between circuits. For example, Stahl wrote that Milnacipran will increase dopamine in the frontal cortex by blocking NE reuptake, because dopamine reuptake sites in the frontal cortex are lacking and the dopamine is normally taken up into the NE sites in that area.

I'm not sure about the dopamine depletion theory. I think serotonin taking a ride through the dopamine circuits where it doesn't belong makes more sense.


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