Posted by desolationrower on March 28, 2009, at 20:13:22
In reply to Re: are there any pure dopamine reuptake inhibitors? » desolationrower, posted by myco on March 27, 2009, at 11:32:33
> Are these available in natural forms? I know nothing of these...time to look at pubmed.
>
> In the end doesn't an agonist produce the same results as an inhibitor for a step in the pathway?...or do you get a "serge" after the inhibitor wears off?
>
> myco
>
> -----------------
>
>
> > dopamine beta-hydroxylase
> >
> > but dopamine agonists aren't the same as substances which block teh DAT.
> >
> > -d/r
>
>agonist will have some distribution in the brain. an inhibitor will have a different one. and the inhibitors effects will be much stronger where the enzyme is more prevalent. mao and comt don't have the same distribution, either in brain structures, or extra/intra cellularly, neuronal/glial, etc.
mentioned enzyme is the one that takes DA->NA. i i think disulfiram is an inhibitor.
-d/r
poster:desolationrower
thread:886970
URL: http://www.dr-bob.org/babble/20090322/msgs/887462.html