Posted by bleauberry on March 21, 2009, at 16:49:09
In reply to anyone done better on lexapro/citalopram than zolo, posted by linkadge on March 21, 2009, at 9:51:51
Both felt like the typical SSRI thing. You know what I mean. But there were some differences.
My comparison is slightly clouded, because along with those two ADs I was also on 500mg Depakote and 5mg Zyprexa the whole time. With those as the backdrop, here is what I experienced:
Lexapro. A general worsening of mood, sometimes outright crying fits of despair. Only 3 hours one random morning did I feel wonderful. Other than that, it did not really do much for depression overall except slightly numb it, and it did zip for anhedonia. Side effects were fairly mild though. Some start up anxiety was pretty bad. AFter that, calm and sleepy. Sex drive was fairly ok, some anorgasmia, but ability was ok.
Zoloft. Felt an immediate boost the first day. Then it kind of faded away, but overall was better than Lexapro the whole time. No more crying spells. Depression was indeed improved some, but as with all SSRIs, it did zilch for anhedonia except make it worse. You know, that SSRI numbing thing. Anorgasmia was worse on Zoloft than Lexapro, but desire and ability were fairly ok. Many things make my ears ring louder than usual. Zoloft was a lot worse than Lexapro in that regard.
If I was limited to just those two meds and had to pick one, I personally would go for Zoloft.
Thank goodness there are other choices.
I really like Dr Gillmans strategies of combining his apparent favorite SSRI (Zoloft) with TCAs for a true SNRI combination that can be custom tailored. All the available SNRIs have such low action on NE it is almost inaccurate to call them SNRIs.
poster:bleauberry
thread:886368
URL: http://www.dr-bob.org/babble/20090313/msgs/886437.html