Posted by bleauberry on March 7, 2009, at 18:47:09
In reply to Re: Liver Enzymes and Poop out, posted by NewQuestions on March 6, 2009, at 8:30:25
> Can you explain by triggers its own metabolism?
Well actually, scientifically, no I can't. I am not scientifically schooled like some folks here, and I did not get thoroughly engulfed in that particular topic of Zoloft, only that I have read about it three different times from three different sources, one of them being pubmed.
I do not know whether Zoloft increases activity of the liver enzyme that metabolizes it? That might be what happens.
Here's the pattern:
Someone has been on Zoloft 50mg for a month.
They now take a blood level and record it.
They stay on 50mg for year.
After the year they take another blood level.
The new blood level is lower than the one a year earlier, even though the dose didn't change.
A higher dose, maybe 75mg for example, is now needed to get the same blood level they used to get from 50mg.Hopefully SLS or Larry Hoover will pop in with an answer. If not, re-ask this question in a new post directed at them. They are more expert at this scientific stuff than I am.
You could also go to pubmed.com and do some creative searches there. Maybe keywords like "zoloft dosage creep"; "zoloft creep"; "zoloft blood level"; "zoloft serum"; stuff like that. You'll have to look through a lot of abstracts to find the ones you are looking for, but they are there.
poster:bleauberry
thread:883934
URL: http://www.dr-bob.org/babble/20090304/msgs/884305.html