Posted by zzzz7 on February 28, 2009, at 18:24:32
In reply to Re: Being Med-Sensitive., posted by SLS on February 23, 2009, at 16:17:59
SLS, this is from a post I made two months ago. I have a case similar to that of NewQuestions'. Right now, I'm off SRIs totally, and when I get depressed .1mg of Requip works immediately.
From 1997 to 2006 I was on large amounts of SRI drugs. At various points, I was on 400mg clomipramine with 100mg Luvox, 110mg Prozac, 100mg Prozac and 400mg ProVigil, and the like.
in 2006 I entered a deep depression after a sporting injury that caused me to go from a high level of physical activity to none at all for several months. To get out of it, I pushed serotonin levels even higher than I had before. I assumed that drugs were pooping out on me. I even added small amounts of 5HTP. All of this seemed to make things even worse. I backed way off when I developed signs of serotonin syndrome. As I backed off, I felt better. The lower I went, the better I felt. I went down to 1mg Lexapro for a while. I felt better, but still slightly depressed. Then, all the way down to two sand-sized grains of Lexapro. Finally relief. I experimented some more by going off SRIs altogether (in this case Lexapro). The depression came back. So, apparently I'm hyper-sensitive to serotonin (and the same turns out to be case for DA; I found this out by decreasing doses of amatadine to lower serotonin levels when I had taken too much of the SRI).
The problem is that something like exercising will increase DA levels such that I get depressed. One grain too much on Lexapro, I get depressed. I sit on this knife's edge between DA and 5HT, and it's tough not to fall off one side.
poster:zzzz7
thread:881677
URL: http://www.dr-bob.org/babble/20090223/msgs/883117.html