Posted by Vincent_QC on February 28, 2009, at 7:32:44
In reply to Re: Clomipramine (Someone else take that AD now) ??? » Vincent_QC, posted by yxibow on February 27, 2009, at 17:31:55
> > Since my last thread, I don't recieve real answers about the Clomipramine.
> >
> > I was wondering if i'm the only one to use it on the babble forum for SAD and GAD and BDD...and also I want to know if it's normal that I feel exhausted, like I don't sleep since a lot of times, even if I sleep more than 6 hours at night... I also want to know how you can call this "problem" : Since I take the Clomipramine, I can't stop thinking about anything...I'm lying in my bed and inside my head I think more than usual...it's like I lived again the past 3 years of my life...the gods and bads moments... I always think and think...and that's make me crazy and a lot tired...and I feel a lot nostalgic...That's really strange...
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> Feeling nostalgic for times when things felt 'better' is not something uncommon -- I do it a fair bit.
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> But we do live in the Here and Now, the present and its important to recognize that strength lies in doing things, being more active to progress to a better state.
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> That being said, I don't think there's anything wrong with looking at the past as long as one doesn't continuously live in the past. But maybe I'm overemphasizing what you are saying.
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> The clomipramine activate a lot my minds but don't give me more energy...I fear that I will endend up like the Prozac at more than 30mg, I mean that I will feel a lot excited and anxious, with no good effects on my SAD or GAD...and at the same time a lot tired...Since the Clomipramine is the more powerfull non-selective of the serotonin reuptake, I suppose it's relatively close to the Prozac effect no???
> >
> > Anyway...is it a manic state or what? I really don't like that... I just want to stay in my bed all day long, feeling tired as hell but at the same time I can't sleep and I feel anxious...I hate that...
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> I don't think it sounds like a 'manic' state.... it sounds like insomnia, foremost for sure.
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> > I'm wondering why I was not able to tolerate the heart effect of the Parnate, since at least with the Parnate, I see already a difference in my SAD level and my GAD level also...
> >
> > Anyway, some help or some advises will help me a lot...thanks for your input...
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> How much Anafranil are you taking? I currently take it for depression and potentially for an OC factor of a complex disorder.
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> When I went above 75 (to 100)mg the NE factor in it was too strong I think and it started to contribute to less functionality.
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> You may be experiencing anxiety due to norepinephrine factors, which can induce anxiety in those susceptible to it. I believe it is dose dependent.
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> If you continue to have problems with Anafranil, you might want to think to switch to Luvox (or Paxil, which does carry a possible moderate weight gain, but similarly is better for anxiety as is Luvox being not quite so activating.)
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> As for the tiredness, clomipramine, though an SRI, does have more side effects being a TCA.
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> The aforementioned SSRIs are a bit cleaner and though 'sleepier' SSRIs may not be as much as Anafranil.
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> The only thing with Paxil besides weight is that you must be sure to keep up with medication because of withdrawal issues.
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> BDD (if I'm reading it as Body Dsymorphic) is sort of in the OC Spectrum disorder range, so perhaps that is why you are on Anafranil if you went through other agents, I'm not sure ?
>
> -- tidings
>
> Jay
>
> Jay
>Hi Jay,
I Can assure you than thinking always about my past is not a sign that I feel "better"!!! I don't live in the past and I dont't want to live in the past, but the Clomipramine or all the newer SSRI's seem to have this kind of activation on the thoughts, especially the past...negative or good experiences...The fact that I can't stop thinking make me feel a lot tired at daytime... for the Insomnia, I use Seroquel (50mg) at bedtime and I can sleep 6 hours in a row but I feel tired at daytime as well...and its not because of the Seroquel next day sedation or accumulation of it into my blood...the regular seroquel have a half-life of around 8 hours...so that's not the cause of my daytime sedation, I had it before I begin to use the Seroquel anyway...I totally agree with you on some points but not all of them...The TCA's have more side-effects for the majority of peoples...but it's seem that i'm not like everyone else, cause I always more strong and bads side-effects on newer drugs like all the SSRI's...
For now, i'm on 50mg of Clomipramine, the TCA choice was due to the fact that it was the only class of AD's I never try. The Clomipramine choice was for the SE effect...and it's not linked to my BDD problem. The NE don't make my anxiety worse...in fact, I think it's more good for my SAD or my GAD...
I was on the Paxil or any newer SSRI's, I try all of them with no result on any of the problems, no improve also... I have (SAG, GAD, panic disorder, BDD, depression and lack of enery and motivation) ... No one of them help me to resolve at least one of these problems...I just gain weight on them...The fact that the SSRI's are more "clean" than the TCA's don't make them more tolerable or good... Newer drug are just more safe if take in overdose...that's it...the compagnies who produce the drugs don't want to be sue for death or anything else so they make newer drugs more safe in overdose...but that's not mean they are more efficiently or more good...I had more side-effects on the Cipralex than on any other AD's...The sedation and cognitives problems never resolves after I stop the Cipralex...so for the safeness of the SSRI's, i'm have a lot of skepticism... The Cipralex is suppose to be the more selective drug for the SE...but for me it was the worst experience of my life...Older AD's like Nardil or Parnate are more tolerable...on me...
I just weight gain on the SSRI's...and the Clomipramine seem to be the same because of it's SE effect...selective or not...I already gain some pounds in 3 weeks...without changing anything from my food intake...
That's why I will maybe ask to try the nortriptyline before jumping again in the MAOI's boat...seem like a more good idea...Second generation TCA's seem to be better than the first generation, they hit more the NE with some DA effects as well and they seem to have less anticholinergic side-effects than the older TCA's...
Anyway, thanks for your help jay ;-)
poster:Vincent_QC
thread:882809
URL: http://www.dr-bob.org/babble/20090223/msgs/883034.html