Posted by desolationrower on February 27, 2009, at 2:34:51
In reply to Scott, Desolation, what's your take on this?, posted by dcruik518 on February 23, 2009, at 14:40:32
> Here's the post from above, I'm thinking of maybe switching from adderall to parnate. Thanks, D
>
> > I've tried taking a number of ssri's with Adderall and none of them seem to work well. In fact they seem to counteract the stimulating effects of the adderall and make me apathetic and lazy. My theoretical explanation for this is that the SSRIs must compete for and win out some of the receptors that would normally go to the Adderall. Does this make any sense pharmacologically? Is what I'm experiencing typical or not? Does it even make any sense to take these two kinds of drugs together? Or would it make more sense to mix adderall with a tricyclic or perhaps even an MAOI?
>
>its not competition for the same receptors (amphetamine itself works (mainly) through the transports for noradrenaline and dopamine, which nerotransmittres then interact with adrenoceptors adn DA receptors; sris block the serotonin transports and so increase serotonin for serotonin receptors, although most sris have some effect on other receptors or enzymes, like sigmas, 5ht2c, or ezymes ), amphetamine doesn't have much effect on serotonin (unless you happen to get some desoxyn). but the sertonergic system inhibits the dopaminergic (maybe the NA) system in various places, the sertonin 2a, 2c, and 3 receptors have been implicated specifically, although its quite complicated. Generally though, boosting serotonin with an sri will cause apathy, even in those not taking stimulants (and if you're apathetic ot begin with, and the pdoc decides to give an sri and refuse to prescibe a stimulant, you could end up in a half year of brain fuzz so deep you can't do anything.) I think that the 'apathy' effect is related to the therapeutic effect, if you worry too much and it just makes you apathetic about pointless trivialities, then you can focus on life and have less anxiety.
sometimes it works to take them together: its not cancelling each other out, just the side effects of each cancelling each other out, adn you get the AD effect of sri and focus from stim w/o any apathy or jitteryness. various combinations can work, its not very predictable whcih will hit the spot, and what little predictive studies have been done haven't been good at helping decide wheter to pick a tca, sri, or whatever.
-d/r
poster:desolationrower
thread:881759
URL: http://www.dr-bob.org/babble/20090223/msgs/882752.html