Posted by iforgotmypassword on February 19, 2009, at 15:51:48
In reply to Re: buspirone dosing » iforgotmypassword, posted by SLS on February 19, 2009, at 15:43:42
> > only with extreme fatigue, pretty much.
>
> You might be profiting from the serotonin 5-HT1a receptor partial agonism of buspirone. I guess you figured that out already. It really sucks that gepirone never made it to market.
>
> One of the problems with buspirone is that it is extensively metabolized into 1PP. 1PP acts a lot like Remeron, a NE alpha-2 antagonist. Tandospirone does the same thing. For me, this is no good. However, for others, it might be one of the reasons buspirone has an antidepressant effect. Flesinoxan is another 5-HT1a partial agonist. It is not metabolized to 1PP. I would have liked to try that one myself.
>
>
> - Scott
>yeah, i worried about that effect since i already have attention and anger issues, but i couldn't find much. i was hoping it wasn't significant, and for some reason even though it's a drug of the same type, i figured it would be even less of an issue for tandospirone as i thought they may have chosen a much cleaner and refined molecule before seeking approval for it. it's too bad that it's still an issue.
do they mention which drugs metabolise into higher levels of the 1-PP metabolite?
poster:iforgotmypassword
thread:881096
URL: http://www.dr-bob.org/babble/20090213/msgs/881135.html