Posted by bleauberry on February 15, 2009, at 17:09:46
In reply to would Zyprexa block the effects of Provigil???????, posted by qbsbrown on February 15, 2009, at 16:17:09
> I was just wondering, doesn't the Provigil (which works great for my depression) increase dopamine, while Zyprexa would be the antagonist?
The two meds did not counteract each other for me. If anything, they seemed to go together well and created a synergistic benefit.
Provigil minimized any daytime tiredness of Zyprexa, while Zyprexa minimized any night-time insomnia of Provigil. Zyprexa helped to restore daytime appetite where Provigil had killed it, and Provigil minimized the increased appetite of Zyprexa. So basically they both muted out each other's side effects. But the mood enhancement effect in terms of anxiety and depression was synergistically more than either med alone. That was just my own personal experience though.
As an unrelated comment, to talk theory such as pro-dopamine plus anti-dopamine is not accurate or helpful. There are too many variables that make the discussion multitudes more complicated than that. Genetics, disease, environmental insults, the varying brain regions a particular drug is most active, and probably a boatload of things yet unknown what these drugs are actually doing at a molecular level.
poster:bleauberry
thread:880323
URL: http://www.dr-bob.org/babble/20090213/msgs/880335.html