Posted by Jimmyboy on February 10, 2009, at 15:31:55
In reply to Re: BUPRENORPHINE, posted by Jim45 on February 9, 2009, at 22:04:33
hey Jim,
Well, first off you don't have to convince me of the theraputic effect of low dose opiates on many many people that fall under the umbrella of "mood disorders". I am there with you.
I think low dose naltrexone at night to combat Mu opiate receptor desensitization ( aka tolerance) is going to be key if anyone tries to use opiates in a theraputic manner. Obviously if the dose escalates and you become a junkie you have a whole 'nother problem compunded on top of the original.
Secondly issue is addictiveness. I think a low dose of a kappa opiate agonist could be key here. kappa agonists lead to highly "un-addictive behavior" The key here would be to keep this very small ( kappa agonists in higher doses are hallucinogenic and dysphoric) - but I think a small amount of kappa agonism could curb a lot of the addictiveness involved with opiates.
anyway, just my 2 cents on the issue.
poster:Jimmyboy
thread:872613
URL: http://www.dr-bob.org/babble/20090203/msgs/879275.html