Posted by Larry Hoover on January 22, 2009, at 17:41:38
In reply to nefazdone + grapefruit, posted by iforgotmypassword on January 22, 2009, at 14:18:49
> i just started nefazodone today, and i already mindlessly had two energy drinks with grapefruit in it. they even had warnings specifically relating to "sensitivity to grapefruit" on them that i did not realize until 15 minutes ago.
>
> as usual, i'm not playing with a full deck. should i be worried? is the grapefruit thing with nefazodone sustantial, particularly given that it's my first dose (i.e. 100mg a few hours ago, 100mg again planned for sometime later today), and the liver issue?I'm not worried at all. The effect should be inconsequential because it was only your first dose.
Nefazodone is both a substrate and inhibitor of enzyme 3A4. It is its own inhibitor. Blood concentrations rise to 2 to 4 times what would be predicted by dose alone, after one week of twice a day dosing. So, please avoid grapefruit hereafter.
I wish you well with this drug.
Lar
poster:Larry Hoover
thread:875459
URL: http://www.dr-bob.org/babble/20090104/msgs/875492.html