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Re: Generic Seroquel » Phillipa

Posted by yxibow on January 21, 2009, at 19:40:01

In reply to Re: Generic Seroquel » yxibow, posted by Phillipa on January 21, 2009, at 10:38:21

> I thought it was fairly new. What's your take on it being an ad? Phillipa

Ad -- I assume you mean antidepressant and not advertisement ?

Seroquel is an augmenter and I wouldn't say first line augmenter until someone has gone through other monotherapy with such things as SSRIs.

If they prove not terribly successful, a small, carefully prescribed dose of a new generation antipsychotic to augment would be one possible choice as it has been in difficult OCD cases.

It certainly has serotonin changing properties, through a blockade, not a reuptake model, but either way, yes, you could call it an adjunct antidepressant.

Then again some doctors consider Lamictal to be an antidepressant in its own right, and also could be an augmenter.

Once you enter polypharmacy, which really should be done with a psychopharmacologist or an experienced psychiatrist, the combination and multiplication of agents can become quite complex, each patient probably on some combination to the milligram not heard a lot of before necessarily.

And so monitoring side effects become important, and only one thing should be added at a time so that you know what upset the last balance.

But I stray from the question -- is it alone an antidepressant, no.... it still remains a neuroleptic foremost if its used alone. It may lift some people with severe depression out of what they have, but by drug class of course its not defined as such.

I believe Abilify is the only one marketed towards TRD at the moment, I'm not sure.


If I got your question wrong as an advertisement -- I'm not sure where that fits. Its been known that Teva has been challenging to have generic Seroquel and I do believe that XL is a patent extender but might be useful for a very small population. I've thought of it myself.

Personally though I generally advocate generics, I am a little leery myself about taking generic Seroquel, not because I love the warm and fuzzy (yes, levity..) AstraZeneca (I get bottles marked with "ZEN" -- amusing coincidence of words) but because I have been on it so long that I have had some side effects of such rarity that I don't want any possible change in the blood level of the drug that is a catch-22 for me to change.


Long post, but answers however you had posted it

-- Jay

 

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URL: http://www.dr-bob.org/babble/20090104/msgs/875347.html