Posted by Vincent_QC on January 10, 2009, at 8:28:40
In reply to Re: Switch from Parnate to (TCAs, Cymbalta)?Help ;-), posted by desolationrower on January 10, 2009, at 1:48:39
> HI vincent. If you haven't answered to sris before, i would think it best to go right to a TCA. duloxetine is more of a sri than nri. Do you have reboxetine in canada? That would be good, or desipramine, if you want an energising drug with low weight gain. Of course any drug the nri will increase heart rate and possibly blood pressure affect.
>
> Try also to remember drugs can take a while to take effect; you need to give them time to give their benefit.
>
> -d/rHi -d/r ;-)
Thanks for the informations, that's very helpfull...No, reboxetine is not avaible yet in Canada...health Canada is very slow on the release of new AD's drugs...it goes on the list with Emsam, Pristiq and many others drugs that we don't have here...Yeah, for the Cymbalta, I will avoid it, since I know it's made like the Effexor-XR, with the small rounds balls inside. It will not work on me, even if I double the dose...That's what I do with the Effexor-XR and it never work, in fact, between 375 and 450 of Effexor-XR, I never felt something except an increase in my benzo drugs intake, more anxiety, more bad habit like smooking more cigarettes, drink more coffee, eat more fast food and things like that. You also specified it's more a SRI than a NRI...I remember having read somewhere and also hear it from my Pdoc that Cymbalta have a more strong noradrenaline inhibition action than serotonin action...but well, I don't lost my time with it, especially if it will not be absord by my intestine...
So, Desipramine seem to be a more selective and strong NE with an interresting side-effects profile, it's what you told me and what I read also, in fact, more good than Nortriptyline...I should ask for it, since I lack any energy or motivation do to anything...I just feel exhausted all the time. I have insomnia at night so I don't know if it will help with this or not?...Do you know what is the target dose of Desipramine to treat someone with all these disorders? (social phobia, panic disorder with agoraphobia, general anxiety disorder and depression)...
I also see in the list of avaible drugs in Canada that we have something call Doxepin, it's another TCA but it seem to be a lot sedating and work more for anxiety disorder...do you know that drug a little bit or try it before? We have also the Maprotiline, who seem to be more a "tetracyclic antidepressant". And another TCA call "Trimipramine" who seem to be a lot like Doxepin...so I suppose major weight gain and also a lot more sedation also...
I'm also aware that drug who play more in the NE field can cause more blood pressure and heart problems...but nothing will beat the problems I had with the Parnate, so in this regard, I don't fear any TCA's...I just fear the weight gain and the too much "Daytime sedation), that I already have when i'm not on an AD's...
Anyway, thanks for your help, that was really interresting for me, I think I will probably ask for Desipramine, since it's seem to be the more interresting and promising for my kind of problems...
Have a nice day!
Vincent ;-)
poster:Vincent_QC
thread:872941
URL: http://www.dr-bob.org/babble/20090104/msgs/873129.html